Received: August 12, 2008
Accepted: October 10, 2008
Ref: Ekong MB, Igiri AO, Egwu AO. Histomorphologic alterations of the cerebellum of Wistar rats following Amodiaquine plus Artesunate administration. Internet Journal of Medical Update. 2009 July;4(2):15-18.
HISTOMORPHOLOGIC ALTERATIONS OF THE CEREBELLUM OF WISTAR RATS FOLLOWING AMODIAQUINE PLUS ARTESUNATE ADMINISTRATION
Mr. M. B. Ekong†, Mr. A. O. Igiri†, and Mr. A. O. Egwu‡
†Department of Anatomy, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria
‡Department of Anatomy, Faculty of Basic Medical Sciences, Ebonyi State University, Abakiliki, Nigeria
(Corresponding Author: Mr. A O Egwu, Department of Anatomy, Faculty of Basic Medical Sciences, Ebonyi State University, Abakiliki, Nigeria, Email: email@example.com)
Amodiaquine and artesunate are two antimalarial drugs sold in combination as Larimal®. This drug is a very effective artemisinin-base combination. This study was to access the effects of amodiaquine and artesunate combination on the histology of the cerebellum. Twenty adult Wistar rats weighing between 150-180g were divided into four groups (A, B, C and D) of five animals each. Group A served as the control and the animals received distilled water, while group B received 8.75+2.86mg/kg of amodiaquine and artesunate combination for three days, group C received 8.75+2.86mg/kg of amodiaquine and artesunate combination for six days and group D received 17.50+5.71mg/kg of amodiaquine and artesunate combination for three days. Histological sections showed destruction of the Purkinje cortical layers in group B, with increased destructions in groups C and D compared to the control. These results reveal that amodiaquine and artesunate combination causes histological alterations, which were dose and time dependent and these may result in cerebellar dysfunction.
KEY WORDS: Amodiaquine; Artesunate; Histopathological alterations; Cerebellum; Larimal; Wistar rats